NPIMap

Individual provider Active NPI

Karen Melinda Isaacs, MD

  • Family Medicine Physician
  • Greer, SC
National Provider Identifier
1457589533
Registry record updated Jun 23, 2025
On this page

Key facts

NPPES NPI Registry
Primary specialty
Family Medicine PhysicianTaxonomy code 207Q00000X
License
93966 Issued in SC
Practice address
109 Physicians Dr
Greer, SC 29650-2446
Phone
(864) 797-9150
Fax
(864) 797-9155
NPI assigned
Jun 26, 2009
Sex
Female
Sole proprietor
No

NPPES NPI Registry

Updated by the provider on Jun 23, 2025

Registry information is reported by the provider to CMS and is not verified. About this source

Specialties & licenses 2

Specialty (taxonomy)CodeLicenseStatePrimary
Family Medicine Physician 207Q00000X 201101212 NC
Family Medicine Physician 207Q00000X 93966 SC Primary

Addresses

Primary practice location

109 Physicians Dr
Greer, SC 29650-2446

Mailing address

300 E McBee Ave FL 4
Greenville, SC 29601-2842
Phone (864) 695-6697

Other practice location 1

2523 Delaney Ave
Wilmington, NC 28403-6003
Phone (910) 772-9202 ext. 402

Electronic endpoints 2

TypeEndpointUseAffiliation
Direct Messaging Address kisaacs6585@direct.nhrmc.org Direct
Direct Messaging Address kisaacs6585@direct.nhrmc.org

Medicare participation

Medicare enrollment files
Medicare fee-for-service enrollment
Enrolled in NC, SC2 enrollments
Eligible to order & refer
  • Part B services
  • Medical equipment
  • Home health
  • Power mobility devices
  • Hospice
Green means eligible to order or refer.

Enrollment records 2

Enrollment IDStateProvider typePAC IDDetails
I20120814000677 NC Practitioner - Family Practice 0345496923 Reassigns benefits to 3 organizations
I20250428004266 SC Practitioner - Family Practice 0345496923 Reassigns benefits to 1 organization

Care Compare profile

Medicare Care Compare
Specialty
Family Practice
Education
Wake Forest University School of Medicine, 2009
Medicare assignment
Accepts the Medicare-approved amount as payment in full
Group practices
Prisma Health University Medical GroupGroup PAC ID 8325950983, 2,467 clinicians

Practice addresses (Care Compare)

109 Physicians Dr
Suite a
Greer, SC 29650-2446
Phone (864) 797-9150

Hospital & facility affiliations

  • Prisma Health Greer Memorial Hospital Hospital, Spartanburg, SC, CCN 420033
  • Watauga Medical Center Hospital, Boone, NC, CCN 340051
  • Prisma Health Greenville Memorial Hospital Hospital, Greenville, SC, CCN 420078
  • Prisma Health Patewood Hospital Hospital, Greenville, SC, CCN 420102

National Provider Directory

National Provider Directory
Medicare enrollment (NPD)
Enrolled
Credentials
Doctor of Medicine

State licenses

LicenseStateTypeSpecialty
201101212NCMDFamily Medicine Physician
93966SCMDFamily Medicine Physician

Practice roles

OrganizationSpecialtyStatusNew patients
Novant Health New Hanover Regional Medical Center LLC CurrentSince Feb 1, 2021 Accepting new patients
Appalachian Regional Medical Associates, Inc. Family Medicine CurrentSince Apr 6, 2023 Accepting new patients
Novant Health Medical Group Coastal Region, LLC Current Accepting new patients
NMG Health Services LLC CurrentSince May 1, 2021 Accepting new patients
Novant Health New Hanover Regional Medical Center LLC Current Accepting new patients
Prisma Health University Medical Group Family Medicine CurrentSince Jun 23, 2025 Accepting new patients
Prisma Health University Medical Group CurrentSince Jun 23, 2025 Accepting new patients
Novant Health New Hanover Regional Medical Center LLC Family Medicine CurrentSince Feb 1, 2021 Accepting new patients
Novant Health Medical Group Coastal Region, LLC Family Medicine CurrentSince May 1, 2021 Accepting new patients
Health Sciences Foundation Inc. Past Accepting new patients
Prisma Health-Upstate Past Accepting new patients

Locations

148 Highway 105 Ext
Ste 102
Boone, NC 28607
Phone (828) 257-2946

211 Milton Brown Heirs Rd
Boone, NC 28607
Phone (828) 264-6720

336 Deerfield Rd
Boone, NC 28607
Phone (828) 263-1211

800 Jefferson St
Ste 112
Whiteville, NC 28472
Phone (910) 642-8164

2523 Delaney Ave
Wilmington, NC 28403
Phone (910) 763-5522

5301 Wrightsville Ave
Wilmington, NC 28403
Phone (910) 452-8100

1725 New Hanover Medical Park Dr
Wilmington, NC 28403
Phone (910) 662-9300

2221 S 17th St
Wilmington, NC 28401
Phone (910) 662-7720

2131 S 17th St
Wilmington, NC 28401
Phone (910) 342-3000

210 Freeman Farm Rd
Duncan, SC 29334
Phone (864) 968-5123

300 E McBee Ave
Fl 4
Greenville, SC 29601
Phone (864) 522-8615

109 Physicians Dr
Ste A
Greer, SC 29650
Phone (864) 797-1050

Interoperability endpoints

  • Direct secure messaging: kisaacs854979@direct.ghs.myhfn.org
  • Direct secure messaging: kisaacs225938@direct.unc.nchie.net

Organizations & group practices 15

Organizations this provider is connected to: Medicare benefit reassignments (the organization bills Medicare for this provider’s services), Care Compare group memberships and National Provider Directory roles.

View all 15

Hospital & facility affiliations 49

Hospitals and other facilities this clinician is affiliated with according to Medicare Care Compare.

View all 49

NPI Registry JSON

The complete NPPES record for this NPI in the NPI Registry API format.

{
    "created_epoch": "1245974400000",
    "enumeration_type": "NPI-1",
    "last_updated_epoch": "1750636800000",
    "number": "1457589533",
    "addresses": [
        {
            "country_code": "US",
            "country_name": "United States",
            "address_purpose": "MAILING",
            "address_type": "DOM",
            "address_1": "300 E MCBEE AVE FL 4",
            "city": "GREENVILLE",
            "state": "SC",
            "postal_code": "296012842",
            "telephone_number": "864-695-6697"
        },
        {
            "country_code": "US",
            "country_name": "United States",
            "address_purpose": "LOCATION",
            "address_type": "DOM",
            "address_1": "109 PHYSICIANS DR",
            "city": "GREER",
            "state": "SC",
            "postal_code": "296502446",
            "telephone_number": "864-797-9150",
            "fax_number": "864-797-9155"
        }
    ],
    "practiceLocations": [
        {
            "address_1": "2523 Delaney Ave",
            "address_purpose": "LOCATION",
            "city": "Wilmington",
            "state": "NC",
            "postal_code": "284036003",
            "country_code": "US",
            "telephone_number": "910-772-9202 x402",
            "fax_number": "910-772-9452",
            "country_name": "United States",
            "address_type": "DOM"
        }
    ],
    "basic": {
        "last_name": "ISAACS",
        "first_name": "KAREN",
        "middle_name": "MELINDA",
        "name_prefix": "Dr.",
        "credential": "MD",
        "sole_proprietor": "NO",
        "sex": "F",
        "enumeration_date": "2009-06-26",
        "last_updated": "2025-06-23",
        "certification_date": "2025-06-23",
        "status": "A"
    },
    "taxonomies": [
        {
            "code": "207Q00000X",
            "taxonomy_group": "",
            "desc": "Family Medicine",
            "state": "NC",
            "license": "201101212",
            "primary": false
        },
        {
            "code": "207Q00000X",
            "taxonomy_group": "",
            "desc": "Family Medicine",
            "state": "SC",
            "license": "93966",
            "primary": true
        }
    ],
    "identifiers": [],
    "endpoints": [
        {
            "endpointType": "DIRECT",
            "endpointTypeDescription": "Direct Messaging Address",
            "endpoint": "kisaacs6585@direct.nhrmc.org",
            "affiliation": "N",
            "use": "DIRECT",
            "useDescription": "Direct",
            "contentType": "OTHER",
            "contentTypeDescription": "Other",
            "contentOtherDescription": "CDA/PDF/TXT",
            "address_1": "2523 Delaney Ave",
            "city": "Wilmington",
            "state": "NC",
            "country_code": "US",
            "postal_code": "284036003",
            "country_name": "United States",
            "address_type": "DOM"
        },
        {
            "endpointType": "DIRECT",
            "endpointTypeDescription": "Direct Messaging Address",
            "endpoint": "kisaacs6585@direct.nhrmc.org",
            "affiliation": "N",
            "address_1": "2523 Delaney Ave",
            "city": "Wilmington",
            "state": "NC",
            "country_code": "US",
            "postal_code": "284036003",
            "country_name": "United States",
            "address_type": "DOM"
        }
    ],
    "other_names": []
}

Other providers in Greer, SC

Sources for this page

Verify at the official NPI Registry.