Individual provider Active NPI

Brianna Nicole Frame, MD

  • Obstetrics & Gynecology Physician
  • Holly Springs, NC
National Provider Identifier
1013590553
Registry record updated Aug 26, 2025
On this page

Key facts

NPPES NPI Registry
Primary specialty
Obstetrics & Gynecology PhysicianTaxonomy code 207V00000X
License
2025-02483 Issued in NC
Practice address
101 Cotten LN
Holly Springs, NC 27540-8415
Phone
(919) 235-6456
NPI assigned
May 3, 2021
Sex
Female
Sole proprietor
Yes

NPPES NPI Registry

Updated by the provider on Aug 26, 2025

Registry information is reported by the provider to CMS and is not verified. About this source

Specialties & licenses 1

Specialty (taxonomy)CodeLicenseStatePrimary
Obstetrics & Gynecology Physician 207V00000X 2025-02483 NC Primary

Addresses

Primary practice location

101 Cotten LN
Holly Springs, NC 27540-8415

Mailing address

PO Box 603949
Charlotte, NC 28260-3949
Phone (919) 350-0351

Other identifiers 1

IdentifierTypeStateIssuer
1013590553MedicaidNC

Medicare participation

Medicare enrollment files
Medicare fee-for-service enrollment
Enrolled in NC
Eligible to order & refer
  • Part B services: Yes
  • Medical equipment: Yes
  • Home health: Yes
  • Power mobility devices: Yes
  • Hospice: Yes
Green means eligible to order or refer.

Enrollment records 1

Enrollment IDStateProvider typePAC IDDetails
I20250923004456 NC Practitioner - Obstetrics/Gynecology 1759790330 Reassigns benefits to 1 organization

Care Compare profile

Medicare Care Compare
Specialty
Obstetrics/Gynecology
Education
University of North Carolina at Chapel Hill School of Medicine, 2021
Medicare assignment
Accepts the Medicare-approved amount as payment in full
Group practices
Wakemed Specialists Group LLCGroup PAC ID 2466788377, 868 clinicians

Practice addresses (Care Compare)

101 Cotten LN
Holly Springs, NC 27540-8415
Phone (919) 350-6002

Hospital & facility affiliations

  • Wakemed, Raleigh Campus Hospital, Raleigh, NC, CCN 340069
  • Wakemed, Cary Hospital Hospital, Cary, NC, CCN 340173

National Provider Directory

National Provider Directory
Medicare enrollment (NPD)
Enrolled
Credentials
Doctor of Medicine

State licenses

LicenseStateTypeSpecialty
2025-02483NCMDObstetrics & Gynecology Physician

Practice roles

OrganizationSpecialtyStatusNew patients
Wakemed Specialists Group LLC Obstetrics & Gynecology CurrentSince Sep 22, 2025 Accepting new patients
Wakemed Specialists Group, LLC Obstetrics & Gynecology Current Accepting new patients
Wakemed Specialists Group LLC CurrentSince Sep 22, 2025 Accepting new patients

Locations

210 Ashville Ave
Cary, NC 27518
Phone (919) 235-6460

204 Medspring Dr
Clayton, NC 27520
Phone (910) 775-3130

2400 N Main St
Fuquay Varina, NC 27526
Phone (919) 232-0322

101 Cotten Ln
Holly Springs, NC 27540
Phone (919) 235-6456

101 Holly Creek Rd
Morrisville, NC 27560
Phone (919) 235-6480

10010 Falls of Neuse Rd
Raleigh, NC 27614
Phone (919) 350-1380

8001 T W Alexander Dr
Raleigh, NC 27617
Phone (919) 350-0953

3000 New Bern Ave
Raleigh, NC 27610
Phone (919) 350-7000

3024 New Bern Ave
Raleigh, NC 27610
Phone (919) 350-5318

1030 Siena Dr
Wake Forest, NC 27587
Phone (919) 235-6511

Interoperability endpoints

  • Direct secure messaging: bframe324542@direct.unc.nchie.net
  • Direct secure messaging: bframe290143@directhisp.wakemed.org

Organizations & group practices 3

Organizations this provider is connected to: Medicare benefit reassignments (the organization bills Medicare for this provider’s services), Care Compare group memberships and National Provider Directory roles.

Hospital & facility affiliations 3

Hospitals and other facilities this clinician is affiliated with according to Medicare Care Compare.

NPI Registry JSON

The complete NPPES record for this NPI in the NPI Registry API format.

{
    "created_epoch": "1620000000000",
    "enumeration_type": "NPI-1",
    "last_updated_epoch": "1756166400000",
    "number": "1013590553",
    "addresses": [
        {
            "country_code": "US",
            "country_name": "United States",
            "address_purpose": "MAILING",
            "address_type": "DOM",
            "address_1": "PO BOX 603949",
            "city": "CHARLOTTE",
            "state": "NC",
            "postal_code": "282603949",
            "telephone_number": "919-350-0351",
            "fax_number": "919-350-7687"
        },
        {
            "country_code": "US",
            "country_name": "United States",
            "address_purpose": "LOCATION",
            "address_type": "DOM",
            "address_1": "101 COTTEN LN",
            "city": "HOLLY SPRINGS",
            "state": "NC",
            "postal_code": "275408415",
            "telephone_number": "919-235-6456"
        }
    ],
    "practiceLocations": [],
    "basic": {
        "last_name": "FRAME",
        "first_name": "BRIANNA",
        "middle_name": "NICOLE",
        "name_prefix": "Dr.",
        "credential": "MD",
        "sole_proprietor": "YES",
        "sex": "F",
        "enumeration_date": "2021-05-03",
        "last_updated": "2025-08-26",
        "certification_date": "2025-08-26",
        "status": "A"
    },
    "taxonomies": [
        {
            "code": "207V00000X",
            "taxonomy_group": "",
            "desc": "Obstetrics & Gynecology",
            "state": "NC",
            "license": "2025-02483",
            "primary": true
        }
    ],
    "identifiers": [
        {
            "code": "05",
            "desc": "MEDICAID",
            "issuer": null,
            "identifier": "1013590553",
            "state": "NC"
        }
    ],
    "endpoints": [],
    "other_names": []
}

Other providers in Holly Springs, NC

Sources for this page

Verify at the official NPI Registry.